A study that may be of interest regarding schizophrenia and hippocampal volume indicated by dermatoglyphs

Hi,

I thought this study may be of interest, but apologies if it has already been posted:

Dermatoglyphic correlates of hippocampus volume: Evaluation
of aberrant neurodevelopmental markers in antipsychotic-naïve
schizophrenia

Sunil V.Kalmady a,b, VenkataramShivakumar a,b, S.Gautham b, RashmiArasappa a,b,
Dania A.Jose b, GanesanVenkatasubramanian a,b,n, B.N.Gangadhar a,b

ABSTRACT
Schizophrenia is a disorder of aberrant neurodevelopment marked by abnormalities in brain structure and dermatoglyphic traits. However,the link between these two(i.e.dermatoglyphic parameters and
brain structure) which share ectodermal origin and common developmental window has not been explored extensively.The current study examined dermatoglyphic correlates of hippocampal volume in antipsychotic-naïve schizophrenia patients in comparison with matched healthy controls. Ridgecounts and asymmetry measures for palmar inter-digital areas(a-b,b-c,c-d) were obtained using high resolution digital scans of palms from 89 schizophrenia patients [M:F¼48:41] and 48 healthy controls [M:F¼30:18]. Brain scans were obtained for subset of subjects including 26 antipsychotic-naïve patients [M:F¼13:13] and 29 healthy controls [M:F¼19:10] using 3T-MRI.
Hippocampal volume and palmar ridge counts were measured by blinded raters with good inter-raterreliability using valid methods. Directional asymmetry (DA) of b-c and bilateral hippocampal volume were significantly lower in patients than controls. Significant positive correlation was found between D A and ridge count of b-c with bilateral anterior hippocampal volume. Study demonstrates the utility of dermatoglyphic markers in identifying
structural changes in the brain which may form the basis for neurodevelopment pathogenesis in
schizophrenia.

Cheers Felicity