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First finger length study in Klinefelter syndrome: short fingers + high 2D:4D digit ratio!

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First finger length study in Klinefelter syndrome: short fingers + high 2D:4D digit ratio!

Post  Martijn (admin) on Mon Oct 15, 2012 11:19 am



Klinefelter syndrome is a disorder seen in males only featured with an extra X-chromosome ((XXY) ). About 1 week ago researchers presented the very first study finger length study for this syndrome (KS):

http://onlinelibrary.wiley.com/doi/10.1111/j.2047-2927.2012.00013.x/abstract

"Adult KS individuals were taller than their fathers and had shorter fingers than fathers and male controls. Compared with fathers, male controls and mothers, KS males had shorter fingers relative to height. With regard to 2D:4D, KS individuals had higher 2D:4D than fathers (right and left hands), male controls (right and left hands) and mothers (left hands)."

(The report also suggests that 2D:4D digit ratio might become a helpful to identify the subjects who need testosterone supplementation)



A doctor's video-report describing the typical characteristics in Klinefelter syndrome:


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Martijn van Mensvoort
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Re: First finger length study in Klinefelter syndrome: short fingers + high 2D:4D digit ratio!

Post  Martijn (admin) on Mon Oct 15, 2012 11:52 am


In 2010 a study from India was presented describing the dermatoglyphics in Klinefelter syndrome:
http://www.nmcth.edu/images/gallery/Editorial/ttP6br_santakke.pdf

E.g. more fingerprint whorls or arches, higher AtD angle (a slightly higher positioned t'-triradius shifter towards the ulnar side is a typical feature), lower a-b ridge count.


PS. Earlier studies have indicated that the simian crease is also more common in Klinefelter syndrome; this 1970 study also presents more details about the dermatoglyphics & simian crease in KS:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1468944/pdf/jmedgene00371-0043.pdf

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Re: First finger length study in Klinefelter syndrome: short fingers + high 2D:4D digit ratio!

Post  Parender on Wed Oct 17, 2012 6:19 am

Hi Martijn!

Thank you for the post.

I found the following information at Wikipedia about ‘Klinefelter Syndrome’ which tally with the post and I have found so in my experiences so too. The link is:-

http://en.wikipedia.org/wiki/Klinefelter's_syndrome

I have found the following Physical and Cognitive and developmental or neuropsychological deficits in executing the functions, in those clients who suffer from ‘Klinefelter Syndrome ‘astonishingly same’, as expressed in the report’. You can read there. They say-



Physically:-

As babies and children, XXY males may have weaker muscles and reduced strength. As they grow older, they tend to become taller than average. They may have less muscle control and coordination than other boys their age. During puberty, the physical traits of the syndrome become more evident; because these boys do not produce as much testosterone as other boys, they have a less muscular body, less facial and body hair, and broader hips. As teens, XXY males may have larger breasts, weaker bones, and a lower energy level than other boys. Affected males are often infertile, or may have reduced fertility. Advanced reproductive assistance is sometimes possible. XXY males are also more likely than other men to have certain health problems, which typically affect females, such as autoimmune disorders, breast cancer,vein diseases and osteoporosis.

Cognitive and developmental:-

Some degree of language learning or reading impairment may be present and neuropsychological testing often reveals deficits in executive functions, although these deficits can often be successfully ameliorated through early intervention. There may also be delays in motor development which can be addressed through occupational therapy. XXY males may sit up, crawl, and walk later than other infants; they may also struggle in school, both academically and with sports.

I want to tell friends here, though, I don’t believe every research report easily, but this one is believable without doubt because I have found so. Thank you Martijn I appreciate your efforts regarding posting this very informative post.

Parender Sethi


P.S.
By the way, for readers who don't know what Klinefelter's syndrome is, I mention that 'Klinefelter's syndrome', 47, XXY, or XXY syndrome is a condition in which a human has an extra X chromosome. While females have an ‘XX’ chromosomal makeup, and males an ‘XY’, affected individuals have at least two X chromosomes and at least one Y chromosomes and because of the extra chromosome, individuals with the condition are usually referred to as "XXY Males", or "47, XXY Males, according to Wikipedia.

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